منابع مشابه
High dose chemotherapy in light chain or light and heavy chain deposition disease.
BACKGROUND Conventional chemotherapy for myeloma yield unsatisfactory results in light and/or heavy chain deposition disease [(H)CDD] Because of the well-established dose-response effect of high dose melphalan in multiple myeloma, aiming to dramatically reduce the pathogenic monoclonal immunoglobulin (MIg) level, high dose therapy is a tempting alternative approach. METHODS We treated 11 youn...
متن کاملBortezomib Based Chemotherapy for Light Chain Deposition Disease.
Light chain deposition disease (LCDD) is a rare systemic disorder in which monoclonal light chains are abnormally secreted due to clonal proliferation of plasma cells and get deposited in various organs; the kidneys being the common one to be affected leading to renal failure. Advocated therapeutic options include chemotherapy with alkylating agents and steroids, High-Dose Melphalan (HDM) with ...
متن کاملLight chain deposition disease; there are reasons for confusion
Implication for health policy/practice/research/medical education: Congo red negative nodular deposition of an amorphous, eosinophilic material is the most common pathologic finding in light chain deposition disease in light microscopy. The nodules are a mixture of light chain and mesangial protein and the picture is reminiscent of diabetic nephropathy. Immunoflurescent microscopy usually demon...
متن کاملRecurrent light and heavy chain deposition disease after renal transplantation.
Light and heavy chain deposition disease (LHCDD) is a rare entity with less than two dozen reported cases [1,2]. The term LHCDD was proposed in 1984 as a variant of light chain deposition disease (LCDD), to characterize a subset of patients in whom deposits contain both light and heavy chain antigenic determinants. We present a case of LHCDD in a renal graft and evidence that this process repre...
متن کاملPathomechanisms of cyst formation in pulmonary light chain deposition disease.
Cystic lung light chain deposition disease (CL-LCDD) is a recently described rare disorder characterised by numerous cysts and diffuse monoclonal nonamyloid light chain deposits surrounded by macrophagic giant cells. The mechanisms responsible for cyst development remain unknown. The objectives of the present study were to analyse the major components of the pulmonary extracellular matrix in CL...
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ژورنال
عنوان ژورنال: Leukemia & Lymphoma
سال: 2011
ISSN: 1042-8194,1029-2403
DOI: 10.3109/10428194.2011.622423